Man, I can't really remember but I wouldn't be too worried about it as you're still in the early stages. I do recall that protopic seemed to make my lips a little sore though oddly enough. Not sure if this was caused by the continuous peeling I endured before protopic or the actual drug, but they were sore. I could taste that they were sore too if that makes sense. It was like a metallic taste on my lips. This seemed to dissipate after I got off pro topic. Again, no idea if protopic was responsible.