thank you. Yes, I have heard great things and I actually have been to an Orthomolecular clinic myself which is based on the work of Carl Pfeiffer who had a lot in common with Abram Hoffer, the father of Niacin therapy. However, my brother will not buy into using nutrients and instead leads a life of unhealthy eating, drugs use, and other harmful lifestyle choices. That is why Depression is so hard to beat alone bc you often lack the energy and motivation to change your diet, lifestyle, and add nutrients like niacin.