hi deena, this is a really good time to start a bowel cleanse, try to get all that stuff out of her body, and yah, it's gonna be bumpy. make sure she has someone to talk to, a shoulder to cry on and almost constant support for the first little while.
is she bi-polar at the same time? the two usually go hand in hand, sometimes Depression is mistaken for bi-polar...which are swings from up to down.
the reason for the Bowel Cleanse is that 90% of serotonin is made in the intestines. here is a link by ptree -