I never had lyme. If I had it what I would do is as follows. This is not medical advice just what I speculate I would do as a hypothetical.
What I think would be ideal is major autohemotherapy. This should be done with a UV light treating the blood. I would try 20 treatments.
Next best would be rectal insuflation. Would do about 40 to fifty treatments say 5 days a week, one per day.