Re: methylation testing

Hi Omo,

I accidently tested it once using SAMe 400mg - really severe herxing physical and psychological reaction. I didn't realise at the time but I know know and understand this to be due to being under-methylated and SAMe is quite a generous methyl donor - which will cause rapid detox to ensue with large doses.

I've since found out i'm +/+ for MTHFR and a few other genes within the methylation cycle. = undermethylation (generally)

MTHFR is gingerly treated initially with 1MG of methyfolate and other methyl donors like B12(if tolerable) and THAT TINY dose can cause herxing reaction in MTHFR +/+ (due to that pathway being opened up again and all stored toxins/metal become released through methylation)

So taking 400 times the dose with SAMe - was no surprise i wanted to die that day!!

My boyfriend also took 400mg SAMe with no effects. We since discovered his MTHFR isn't mutated.

SAMe is a pretty good way of determining under-methylation problems. Do it on a free day just in case you have a bad reaction. (don't take if on SSRI's)

Also another indication of methylation issues could be to test the transulfation pathway (CBS gene) which tends to become upregulated when there are MTHFR, MTR, MTRR (methylation ezymatic) problems. Sulfur foods like Cabbage, broccoli, cauliflower, eggs should be problemsome for those with this pathway working too fast.
Load up on these foods for a couple of days and see if you're general symptoms are any worse.
Also urine and sweat smell more ammonia-like due to this pathway working too fast.

I've eliminated high sulfur/ammonia foods due to this upregulation and feel more 'grounded'.

It's only recently i've been learning how important methylation really is - that cycle does SO much for the body...switch on and off genes, detox metals and toxins, synthesise protein, hormones..regulates immune function...etc etc ...it's truly a gigantic biochemical organiser which results in chronic conditions when those enzymes (genes) are slightly or fully dysfunctional.