CureZone   Log On   Join
Re: Do I have mercury poisoning? List of symptoms
dvjorge Views: 5,312
Published: 10 years ago
This is a reply to # 2,018,489

Re: Do I have mercury poisoning? List of symptoms

Mercury induces a polarized Th2 immune response. There isn't WAY of curing candida with no cell-mediated immunity.

Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells
Anshu Agrawal1, Poonam Kaushal, Sudhanshu Agrawal, Sastry Gollapudi and Sudhir Gupta
+ Author Affiliations

Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
↵1 Correspondence: Division of Basic and Clinical Immunology, Med. Sci I C-240, University of California, Irvine, CA 92697, USA. E-mail:

Next Section

Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2-skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2-promoting effect through modulation of functions of dendritic cells (DC). Thimerosal, in a concentration-dependent manner, inhibited the secretion of LPS-induced proinflammatory cytokines TNF-α, IL-6, and IL-12p70 from human monocyte-derived DC. However, the secretion of IL-10 from DC was not affected. These thimerosal-exposed DC induced increased TH2 (IL-5 and IL-13) and decreased TH1 (IFN-γ) cytokine secretion from the T cells in the absence of additional thimerosal added to the coculture. Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-α, IL-6, and IL-12p70 by DC and IFN-γ secretion by T cells. These data suggest that modulation of TH2 responses by mercury and thimerosal, in particular, is through depletion of GSH in DC.

Printer-friendly version of this page Email this message to a friend
Alert Moderators
Report Spam or bad message  Alert Moderators on This GOOD Message

This Forum message belongs to a larger discussion thread. See the complete thread below. You can reply to this message!


Donate to CureZone

CureZone Newsletter is distributed in partnership with

Contact Us - Advertise - Stats

Copyright 1999 - 2022

1.828 sec, (1)