Yes and no.. The first day I took it, I took 12,000mg however, I didn't take it all at once. I chose to take it in divided doses during the morning, afternoon, evening and just before bedtime, which is the most crucial time for me.
It worked instantly. I followed the Pyroluria protocol (high doses of zinc b6,b5,b3 etc.)including many amino acids for over 2 months, and nothing has worked to effectively stop or prevent them. This must be the B vitamin that I'm deficient of because when I look it up in Joan Mathews Larsons book on orthomolecular psychiatry, one of the symptoms she lists as an Inositol deficiency is panic attacks/disorder. I wish I had paid heed to it earlier..