The best combination of drugs is no drugs at all
You are certainly entitled to your opinion, but in my opinion the best combination of drugs is no combination at all. The best combination, by far, is a healthy diet and lifestyle along with the healing items found in nature which we have used and developed alongside for thousands of years.
For the very great part, those medicines you are so impressed with interfere with the actions of the 300 plus hormones/chemicals. The compounds which make up mainstream medicine are not natural and the body recognizes them as toxins. Which no doubt plays a very large role in the fact that over 95% of those medicines have side effects - which often lead to other conditions and complications and still more drugs in a never ending cycle. It's a great model for profits but a horrible one for healing and humanity.
If mainstream drugs are so wonderful and so life-extendiing, why do you suppose that the most heavily medicated country in the world by far ranks behind over 35 other countries in longevity? Most of our increase in lifespan has come as a result of better sanitation, better access to primary trauma care, and until recent decades, better nutrition. Indications in recent years is that lifespans in the US may actually be starting to decline.