I believe that anything that doesnt contain b2 would "deplete" the body for the vitamin, and also the other vit Bs.
yes, they are needed in most processes of the body; so if you take boron in therapeutic dosages, or Iodine or preferably both, it will start a process that puts a demand on the body to work on a higher level.
Thats why we stress the companion vits and minerals in the Iodine protocol. A good diet of course + supplements as needed.
After taking boron in excess the last four years I can assure that none of these symptoms have reappeared, but I had some tendencies while I was hypo T (before Iodine and boron)