I'm not sure about something: methyl/folate trapping is because of low B12, and (folate/methyl) accumulates, and methionine recycling is impaired, causing low sam-e; the treatment would be B12 (the regular kind, not the metyl B12, because we already have enough methyl trapped and it would make us feel worse), but I do not know when to introduce methionine or Sam-e: after enough methyl was untrapped by B12 use (I do not know if sam-e increases methyl trapping), or from the begining because????(not sure) sam-e does not cause methyl increasing, because it uses it up immediately????