dosing and uses

SSKI -potassium-iodide-343399">http://reference.medscape.com/drug/pima-syrup- SSKI -potassium-iodide-343399


Adult Dosing & Uses
Dosing Forms & Strengths

tablet

* 65mg
* 130mg

oral solution

* 65mg/mL
* 325mg/mL

oral solution (concentrated)

* 1g/mL

Radiation Emergency

Indicted during environmental radiation emergency to block uptake of radioactive Iodine isotopes in thyroid and reduce risk of thyroid cancer

130 mg PO qDay; not to exceed 1 dose/24 hr

Ideally initiate 1-48 hr prior to exposure

Continue daily dose until exposure risk has passed and/or until other measures (eg, evacuation, sheltering, control of the food and milk supply) have been successfully implemented

Risk reduction with acute exposure

* KI initiated shortly before or immediately after acute exposure: 90-99% risk reduction
* KI initiated within 3-4 hr after acute exposure: 50% risk reduction
* KI initiated up to 12 hr after acute exposure: limited benefit may be achieved

Expectorant

SSKI : 300-600 mg PO TID/QID
Thyrotoxic Crisis

250-500 mg (5-10 gtt of 1 g/mL) PO q4hr
Preoperative Thyroidectomy

50-250 mg (1-5 gtt of 1 g/mL) PO TID for 10-14 days
Other Indications & Uses

Expectorant in asthma, chronic bronchitis, emphysema

Cystic fibrosis, chronic sinusitis (adjunct)

Thyrotoxic crisis; pre-thyroidectomy to decr thyroid vascularity

Thyroprotective: minimizes risk of thyroid neoplasm in radiation exposure

Pediatric Dosing & Uses
Dosing Forms & Strengths

tablet

* 65mg
* 130mg

oral solution

* 65mg/mL
* 325mg/mL

oral solution

* 1g/mL

Radiation Emergency

Indicted during environmental radiation emergency to block uptake of radioactive Iodine isotopes in thyroid and reduce risk of thyroid cancer

Infants <1 month: 16.25 mg PO qDay

1 month-3 years: 32.5 mg PO qDay

3-18 years: 65 mg PO qDay

Adolescents weighing >70 kg (154 lb): 130 mg PO qDay

18 years or older: As adults; 130 mg PO qDay Not to exceed 1 dose/24 hr

Ideally initiate 1-48 hr prior to exposure

Continue daily dose until exposure risk has passed and/or until other measures (eg, evacuation, sheltering, control of the food and milk supply) have been successfully implemented

Risk reduction with acute exposure

* KI initiated shortly before or immediately after acute exposure: 90-99% risk reduction
* KI initiated within 3-4 hr after acute exposure: 50% risk reduction
* KI initiated up to 12 hr after acute exposure: limited benefit may be achieved

Neonatal Graves Disease

SSKI: 1 gtt PO q8hr
Expectorant

SSKI: 60-250 mg PO QID
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