I am far from an expert here, and Michael knows a lot more than me. But, if that was happening to me, I would not be taking ES. You may be allergic or something. I would do one of the flushes that doesn't use it, like Doc Sutter's or Dave Frahm's. If you feel like a stone is stuck, however, then I think you have to take a dose, or maybe try ACV first. Apparently, this is rare. But I am in the minority that it has happened to, a few times. And either ES or ACV got it unstuck.