I have not taken Alpranax nor used Xanax. When I was suffering from anxiety I started on Dr. Hulda Clark 's programs. I took high doses of turmeric (see recipes online) and the anxiety was greatly reduced. Accoring to Dr. Clark the anxiety was due to the toxins being produced in my intestine by Shigella and or toxin producing E. Coli. At that time I had undiagnosed gluten sensitivity - Celiac Disease and non-celiac sprue. About 10% of people with IBS have been misdiagnosed and actually have Celiac Disease so you might check with your Dr. and find out if you had complete testing for this autoimmune problem. For the complete list of tests needed see the information pages at Celiac.com.