I started using F165/bean (scalar device) in December 2009 (or maybe last few days of November 2009, don't remember exactly, but I remember I got my equipment late November 2009)
Doctrine started sometime in the spring of 2010 I think, again don't remember exactly, but it kind of evolved in early months of 2010.
Yes, it took a while and I can say that the biggest problem is ability to reach those pathogens, I mean very often they are dormant and therefore somehow protected and you can't destroy them. And it's a tricky endeavor to find out how to make them reachable. Because you try and try things and nothing works and then you try again and something is working but never until a few days i was able finally to feel a significat difference.