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Drug induced low testosterone levels (Albendazole, Metronidazole, Nifuratel, Tinidazole)
 
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Published: 13 y
 

Drug induced low testosterone levels (Albendazole, Metronidazole, Nifuratel, Tinidazole)


Hello.
In october 2009 i made testosterone level test, and it was 622ng/ml/ after 30 days of self-restraint in self-gratification and sex. (also TSH - 2.68 AB to TPO 41,6 and FREE T4) 13.9, I made this test, because of acne. As im remember i have had perfect erectile function and sex appeal, strong night errections, after 10 days of self-restraint from self-gratification. erections even after day sleep, errection after dinner.

Now i cannot say that all is as good as it was. Morning erections appears 1 from 3 days. And sex drive is much less.

I think reason of this because of drugs, im used int treatment of giardia liamblia.
In short period of 4 month, i had used many drugs:
1000/1/2(mg,t,days) of TINIDAZOLE
250/3/7(mg\t\days) METRONIDAZOLE
than NIFORATEL(macmiror) 200x2/3/7/(mg,t,days)

After this treatment i still got giardia in my analysis. I have waited for 1.5 month and then decided to take ALBENDAZOLE 400mg, one time a day with fat(~50 ml of sunflower oil)for 7days, than stop for 14 days and that again for 7 days; one day, as im remember, ive taked 2 instead of one. This treatment seems was to be effective ,because next analysis for giardia was clear.

New analyses(26.05.11) shows only 386 ng\ml
TESTOSTERONE 386 ng\dl :((( (245 - 1600)
LH 2.77 mmE\ml (0.8-7.6)
FSH 2.69 mmE\ml (0.7 - 11.1)
ESTRADIOL 21.6 pg\ml (0 - 56)
PROLACTINE 173 mE\ml (53 - 360)
free t4 14.9 pmol\l (10 - 25)
free t3 5.47 pmol\l( 1.8 - 6.45)
TSH 2.84 mkmE\ml (0.4 - 4)

Also recently, on transrectal ultrosonagraphy i found that i have prostatite with 1 calcinate.

I surfed internet for information about reproductive toxity of drugs i had used, and found that all of them are reproductive dangerous; Many information about nitrofurans(Nifuratel), metronidazole, and a bit information about albendazole.
Most of all im afraid that this was caused by albendazole. i used it with fat, which increase absorption for 5 times.
I found some papers with experiments on animals, that says that albendazole can cause reproductive degeneration at 30mg\kg. My mass is 80 kg, so i taked 5mg\kg, but with bigger absorbtion with fats that means i taked about 25-30 mg\kg!

I need your opinion on this issue. thanks

 

 
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