Biofilms can definitely complicate the problem as well as too much mucus production. Mucus + biofilm combined can add problems. Thats why i dont like anti-fungal/chemical substances that can irritate the intestinal tract. Seems to add problems by the increase in mucus production. Over irritating substances to the GI tract can cause too much mucus production. The body responds to the irritating substance/toxins by producing mucus. Too much mucus in the intestines or biofilms can act as a barrier for the candida fungus. Making it even more difficult to get rid of.