They are always involved. Kidneys are the filter of the body. If mercury does damage the way it does with lipid peroxidation and oxidative stress and takes up home in all the organs, including the heart as #1 and kidneys as #2, then I don't see why not. I know first hands someone who's creatinine was 2.9 which is dialysis status and after very low and easy chelation of metals, it went down the .9 which is normal. I myself deal with kidney issues as well.
The basics of human biochemistry is simple. The body runs like junk and you put junk in the body, the filters will take more damage than necessary. You put muddy dirty water through a water filter, it'll be dirtier and more damaged than using regular, already clean water. Fortunately for our bodies, kidneys are living cells and regenerate very slowly. Unfortunately for us, you can't just buy and swap kidneys every day like a mechanical part.