Re: Anti-amebic effect of Nystatin

The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures.
Gonçalves AQ, Viana Jda C, Pires EM, Bóia MN, Coura JR, Silva EF.

Laboratório de Doenças Parasitárias, Departamento de Medicina Tropical, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. queiroga@ioc.fiocruz.br

Abstract
In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%).

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