BABESIOSIS: Atovaquone & Azithromycin Vs. Clindamycin & Quinine

Hi 77665 ~~

The failure/mortality rates you are referring to regard patients who are asplenic, elderly, or immunocompromised:

In Europe, most symptomatic patients are asplenic, which contributes to a poor prognosis.  More than 50% of patients become comatose and die.

Following article from the New England Journal of Medicine covers the adverse side effects & cure rates for treatment with these drugs:

Atovaquone and Azithromycin for the Treatment of Babesiosis

Peter J. Krause, M.D., Timothy Lepore, M.D., Vijay K. Sikand, M.D., Joseph Gadbaw, Jr., M.D., Georgine Burke, Ph.D., Sam R. Telford, Sc.D., Peter Brassard, M.D., Diane Pearl, M.D., Jaber Azlanzadeh, Ph.D., Diane Christianson, R.N., Debra McGrath, R.N., and Andrew Spielman, Sc.D.

N Engl J Med 2000; 343:1454-1458 November 16, 2000

Background

Babesiosis is a tick-borne, malaria-like illness known to be enzootic in southern New England. A course of clindamycin and quinine is the standard treatment, but this regimen frequently causes adverse reactions and occasionally fails. A promising alternative treatment is atovaquone plus azithromycin.

Methods

We conducted a prospective, nonblinded, randomized trial of the two regimens in 58 subjects with non–life-threatening babesiosis on Nantucket, Massachusetts; on Block Island, Rhode Island; and in southern Connecticut. The subjects were assigned to receive either atovaquone (750 mg every 12 hours) and azithromycin (500 mg on day 1 and 250 mg per day thereafter) for seven days (40 subjects) or clindamycin (600 mg every 8 hours) and quinine (650 mg every 8 hours) for seven days (18 subjects).

Results

Adverse effects were reported by 15 percent of the subjects who received atovaquone and azithromycin, as compared with 72 percent of those who received clindamycin and quinine (P<0.001). The most common adverse effects with atovaquone and azithromycin were diarrhea and rash (each in 8 percent of the subjects); with clindamycin and quinine the most common adverse effects were tinnitus (39 percent), diarrhea (33 percent), and decreased hearing (28 percent). Symptoms had resolved three months after the start of therapy in 65 percent of those who received atovaquone and azithromycin and 73 percent of those who received clindamycin and quinine (P=0.66), and after six months no patient in either group had symptoms. Three months after the completion of the assigned regimen, no parasites could be seen on microscopy, and no Babesia microti DNA was detected in the blood of any subject.

Conclusions

For the treatment of babesiosis, a regimen of atovaquone and azithromycin is as effective as a regimen of clindamycin and quinine and is associated with fewer adverse reactions.

Source Information

From the Division of Infectious Diseases (P.J.K., D.C.) and the Division of Research (G.B.), Connecticut Children's Medical Center and the University of Connecticut School of Medicine, Hartford; Nantucket Cottage Hospital, Nantucket, Mass. (T.L., D.P., D.M.); the Department of Medicine, Tufts University School of Medicine, Boston (V.K.S.); the Division of Infectious Diseases, Department of Medicine, Lawrence and Memorial Hospital, New London, Conn. (J.G.); the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston (S.R.T., A.S.); the Department of Medicine, Brown University School of Medicine, Providence, R.I. (P.B.); and the Department of Laboratory Medicine, University of Connecticut School of Medicine, Farmington (J.A.). http://www.nejm.org/doi/full/10.1056/NEJM200011163432004

Hope this info clarifies the matter for you!

Cheers ~~ ICU     

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