I don't know if I can really be of any help as I have always been able to clear any blocked ducts before they got too serious. Hopefully my advice doesn't conflict with other's..
I always tried to feed as much as possible off that side, massage quite firm in the area of the blockage and express in the shower, drink lots of water and try to go to bed if possible.
It is likely that she is already doing all of these things but I wanted to include them just in case. I imagine that your sister is feeling quite ill at this stage as it feels like the flu when an infection sets in.
I hope Hv can help you out further so that it can be resolved.