I can't say for sure as I have only been taking the tincture for less than 2 weeks, but what I will say is that I just did my 2nd flush this past Friday and I was much more successful this time around. The first time didn't produce any stones but the 2nd time I literally had hundreds of stones. The only change I made was taking Chinese Bitters and GCG so its possible the GCG dissolved the stones to make them small enough to pass.