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You might want to read jessesmom1987 posts. Has no gallbladder. I -and others- have found them to be quite reassuring, educational, informed. She's done a lot of flushes. Contributed tons of useful info. Only time she reported feeling some pain was one time she didn't take any Epsoms. Protocol she's followed the most is Dr. Sutter's but without ultra phos, and still including the Epsoms. Nowadays goes by shortened username Js.Mom. Anyway many people have done it who have no gallbladder. A. Moritz' main advice for them is to take an ox bile supplement with meals to help digestion on an ongoing basis.