My husband has had definite HSV-3 reactions from it being uncovered after running other things (brucella especially). It's not fun.
My week-long immune reaction from uncovering the measles, mumps and rubella was not fun either. I literally could not leave the house for a week, because of my face being so swollen, and bright red. I had slits for eyes for the entire week..and then when the swelling started going down, I looked like a sharpae (however it's spelled) dog, with massive wrinkles :(