Well it must be detoxing my liver big time, because I am having some kind of reaction. I posted this in the Humaworm section as well and he said that you can most definitely get die-off with milk thistle. He recommended to take less pills and give my liver a chance to get used to it. I'm trying to do that now. Strangest thing really, because I've taken milk thistle in the past combined with other stuff and never had any kind of weird die-off, but take it alone and whammo! Plus I heard the brand I take is considered one of the most potent I guess.