Hi Ladywear - I've been recovering from adrenal fatigue and doing lots of detoxing (including liver) for 15 years. I took milk thistle and dandelion for 14 years, then stopped them about a year ago.
During the first few years I found that detoxing put a big strain on my adrenals, and caused them to relapse numerous times. In recent years my adrenals have gotten stronger, and I've done quite a bit of colon cleansing. I don't know how much of my adrenal improvement is due to the milk thistle and dandelion I took for so many years. My liver is still working hard and detoxing rapidly a lot of the time. I wish I could give you a clearer answer to your question.