I have no problem using antifungals, at the moment I am using capyrlic acid. I have always got terrible reactions when I use zinc, b vitamins and folic acid so bad that I have to stop after a day or two (find it very difficult to urinate). I have always wonder why this is? I have used folic acid in the past for over a month and have had the same reaction - so don't know if it was die off (would it last that long?).