Leptin Resistance and Reverse T3 thyroid

I'm seeing puzzle pieces fitting together with this. Not just with the toxins causing Leptin Resistance, but the other glandular involvements. I specifically had to ask the ND for the Leptin test. Now, being my own detective, I'm seeing how what he's been doing with me with the glands, isn't all that is needed..it's part of what has been needed.

I can see how important it is to be addressing the Lyme toxins, but I won't take the drugs Shoemaker and other's talk about. In fact, I was reading where one of the drugs Shoemaker used to have his patient's taking, was pulled off of the market for causing liver damage (!) But, now I understand better, why the Buhner and Cowden protocols have the herbs in them for clearing Lyme endotoxins, Buhner's especially. And, it's stuff I've heard Newport mention before, but didn't know how important it really was- like the Japanese Knotweed (resveretrol).

>>Leptin resistance also stimulates the formation of reverse T3, which blocks the effects of thyroid hormone on metabolism (discussed below).

Reverse T3

It is well known that thyroid hormones regulate metabolism and that low thyroid hormone production (hypothyroidism) causes low metabolism, but it has only recently been understood that thyroid production can be fine but there can a problem of activation of the hormones inside the cells that can be a major cause of low metabolism.

The thyroid gland secretes an inactive thyroid hormone called thyroxine, also known as T4. This is regulated by thyroid stimulation hormone (TSH) produced by the brain (specifically the pituitary). Normally, the inactive T4 is converted inside the cell to the active thyroid hormone called triiodothyronine (also known as T3). Most doctors will check TSH and T4 levels to see if thyroid levels are normal.

The studies are showing that it is not the production of thyroid that is the problem, but rather it is problem inside the cell that the inactive T4 is not converted to T3 but rather to a mirror image of T3 called reverse T3. The reverse T3 has the opposite effect of T3, blocking the effects of T3 and lowering rather than increasing metabolism.

It is an evolutionary fall-back that was useful in times of famine or in hibernating animals to lower metabolism. Studies are showing that stress and dieting (especially yo-yo dieting) can set this hormone into action as well as chronic illness such as diabetes, chronic fatigue syndrome and fibromyalgia.

The production of reverse T3 is found to be a major method by which the body 'tries" to regain any lost weight with dieting. As soon as the body senses a reduction in calories, the production of reverse T3 is stimulated to lower metabolism. With chronic dieting or stress, the body often stays in this "starvation mode" with elevated levels of reverse T3 and decreased levels of T3, which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).

Testing: There has been a long held belief by endocrinologists and other physicians that adequate thyroid levels can be determined by testing the TSH and T4 levels. Studies are showing that such standard testing will miss 80% of thyroid dysfunction so most endocrinologists and other doctors will tell their patients that their thyroid is fine based on this usual testing. The doctors must run a free T3/reverse T3 ratio.

http://www.huffingtonpost.com/kent-holtorf/long-term-weight-loss---m_b_192933...


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http://www.royalrife.com/hypothyroid.html

Royal Rife is saying the same thing, but how finding high cortisol on an adrenal saliva test, also indicates Reverse T3. Mine was high when it was done some time back. I've never heard this before. The Biotics Research glandular products, are some that the ND has had me using, but not the ones he's talking about for high cortisol and the reversed T3. In fact, the one I've been on for thyroid (GSA), is used for high TSH..mine is not high, it's low.

The reason the ND does the marker tests for the thyroid, even though they show in the "normal" range according to their values, is because like Royal Rife is saying here- they are not in the range they need to be. The Royal Rife healthy range, is not where my numbers are at.

HYPOTHYROIDISM

INTRODUCTION: About 50% of people with health issues have some sort of endocrine problem. Many have thyroid issues. In primary hypothyroidism, the thyroid is the basic issue. With secondary hypothyroidism, the basic problem is with other glands that affect the thyroid. About 80% of those with thyroid problems are women. American men and women are continually dosed with estrogen or estrogen-like compounds in drugs, food (especially soy), water, and air. Excess estrogen interferes with the conversion of T4 to the active T3. Add to this our exposure to chlorine and fluoride in our water. Both of these block the activity of iodine. Also, most Americans have an Iodine deficiency. Many have protein deficiencies. (Many of these concepts are based on research by Dr. Harry Eidenier, Jr., Ph.D.)

DETECTION: This is a combination of looking at symptoms and then tests


TESTS: Tests provide about half of the needed information. Out of 100 patients with the above symptoms, about 10 will have genuine (primary) hypothyroidism. The rest will mostly be excessive adrenal (cortisol) output blocking conversion from T4 to active T3, or low pituitary function leading to low thyroid function. Some cases are excess estrogen or low adrenal function.

- TSH. This is the primary test. The healthy range is about 2.0-4.0. With symptoms and a reading above 4.0, this is probably primary hypothyroidism. With symptoms and a score below 2.0, the problem is probably a weak anterior pituitary. If the TSH is between 2.0 and 4.0, look at the T4, T3, and cortisol.

- T4 (thyroxin) should be in the middle or just above the middle of the normal range.

- T3 or T3 uptake should be in the middle or just above the middle of the normal range. If there are symptoms, and the T4 is in the middle or upper part of its range, and the T3 is in the lower part of its range, the person is an under-converter.

- Cortisol from a salivary adrenal stress test. Blood TSH, T4, and T3 may be fine. But if there are symptoms, cortisol may be high because of stress or excess carbohydrates in the diet. If the cortisol is high, the patient is almost certainly making reverse T3 instead of real T3. Reverse T3 is not a functional hormone but it looks like normal T3 on a blood test. This is often treated with T3 and T3 may relieve symptoms. But it may be better treated as a high cortisol issue. At least half of adrenal issues are excess cortisol output!

- Estrogen is best tested from a saliva sample.

Iodine. Paint a silver dollar size of drugstore tincture of Iodine on your skin. If it soaks in quickly (the stain is gone in less than 24 hours), you need Iodine unless you have an iodine allergy.

Primary hypothyroidism (high TSH) - Biotics GTA and Meda-Stim, 3-6 of each per day. GTA is a thyroid support preparation. Meda-Stim helps convert T4 to T3. These will reduce high TSH 95% of the time. Avoid cabbage family foods and millet.

Weak anterior pituitary (low TSH) - Biotics Thyrostim and Cytozyme PT/HPT. 3-6 of each per day.

Under-converter (low T3) - use Biotics Meda-Stim.

Adrenal - for excess cortisol (reverse T3) use Biotics ADHS, 1 with breakfast and 1 with lunch to lower cortisol. Biotics Meda-Stim, 3-6 per day. This is also a good program for Wilson's Syndrome (Low T3 in the tissues). Consider Biotics Glucobalance. Diet is crucial. Excess carbohydrates will often block progress. If cortisol is low, consider Bezwecken Isocort, 3-6 per day.

Excess Estrogen - Biotics Calcium D-Glucarate (1 twice a day) helps the liver detoxify excess estrogen.









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