Re: hope for the hopeless with fibromyalgia - Wanting to share

Just wanted to share some information on this message board about a all-natural alternative for Vioxx, Celebrex, or Bextra (Xanthones have demonstrated to provide natural relief via direct inhibition of the COX-1 and COX-2 enzymes)** see article at Biochem Pharmacol. 2002 Jan 1;63(1):73-9. (Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.) More Info - , gamma-mangostin concentration-dependently inhibited the conversion of AA to PGE2 in microsomal preparations, showing its possible inhibition of cyclooxygenase (COX). In enzyme assay in vitro, gamma-mangostin inhibited the activities of both constitutive COX (COX-1) and inducible COX (COX-2) in a concentration-dependent manner, with the IC50 values of about 0.8 and 2 microM, respectively. Lineweaver-Burk plot analysis indicated that gamma-mangostin competitively inhibited the activities of both COX-1 and -2. This study is a first demonstration that gamma-mangostin, a xanthone derivative, directly inhibits COX activity. For more information please visit: www.thehealthfruit.com or free info by emailing me at tev44@yahoo.com(free 23 page e-book on this supplement) Todd Tweet