Hi! The first thing that will help get the toxins out is the colon... If you are too constipated to do one of the cleanses with fiber i highly recommend a series of colonics. It is a little intimidating at first but i is so good if your super toxic and clogged up. Another thing that will make a huge difference is sweating. Exercise and find an infrared sauna. The latter will help you sooo much. 30min in one will turn a white towel grey( the towel your sitting on)..... It really helps and will get enough junk out so you can start doing some of the cleanses. After you sweat a couple times.. get the lymph system moving with some exercise and dry brushing (there are instructions on the drybrushing forum)..... these will all really help.. good luck!