So far, I've used it when my skin starts to feel itchy with eczema coming on, and I use it on my cystic acne. I asked RG why my acne would appear to be worse the day after I apply the cream, and RG said that's because it brings up the toxins from underneath before killing them. Usually, the acne would die down the day after.
I also used it on my hubby's spots last night as he's started to break out a little bit due to die-off from Humaworm (we just finished Day 4), and his spots shrivelled up the next day.
So yeah, we love the cream! I'm glad I have a big pot of it! It's terrific value for $$!