The best form is natural D3 from the sun. That is not always possible - especially in winter months in northern climes. I use a product from Biotech which I get from Utopia Silver (and use the discount code of LR001 to get 15% when it is not on sale). I get lots of sun and so do not find it necessary to supplement very day with Vitamin D3, but I would opine that 3000 to 5000 mg a day would be an optimum amount, especially when fighting or preventing cancer.