S-Adenosyl methionine (SAMe) and other finds

I stumbled upon this forum, and thought it might be beneficial for some of you if I share my accidental finds during my recent research on a different subject.

S-Adenosyl methionine (SAM2) is a coenzyme involved in more than 40 metabolic reactions. It is produced and consumed in the liver and is broadly available as a nutritional supplement. It regulates many liver enzymes and activities.

Effect of different doses of S-adenosyl-L-methionine (SAMe) on nicotinic acid-induced hyperbilirubinaemia in Gilbert's syndrome :

http://www.informaworld.com/smpp/content~db=all~content=a787017288


SAMe obviously reduces bilirubin blood levels significantly.
SAMe has become famous as antidepressant - but this only one of its wide range of beneficial effects on metabolic reactions. It seems to help in Arthritis pain management, protection of joint cartilage, healing of liver defects etc.etc. But please google this yourself a bit.

Bilirubin seems to be toxic to the brain and to inhibit proper use of thyorid hormones by the liver. That means with high bilirubin serum levels your entire metabolism may be slowed down despite normal thyorid hormone levels in the blood.

Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: effects of bilirubin and nonesterified fatty acids :

http://jcem.endojournals.org/cgi/content/abstract/76/5/1165


The relationship between the thyroid gland and the liver :

http://qjmed.oxfordjournals.org/cgi/content/full/95/9/559


The next document is referring to a connection between impaired bilirubin breakdown and a phenol-sulfotransferase deficiency:

http://www.newtreatments.org/Sulfur/ga/252/Autism%20and%20phenol-sulphotransf...


There were several references of a connection between a biotin deficiency and high bilirubin, but I had no time to dig any deeper into this biotin/bilirubin relationship. Potentially a biotin supplementation could be helpful.

I find these issues very interesting and worthwhile to be investigated further, maybe someone here in this forum can pick up the ball.

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