Take on an empty stomach
I was told to be sure and take on an empty stomach, like 2-3 hours after eating. (Otherwise it stays in the digestive tract and digests your food.)
I would say, based on the study below, that you shouldn't eat for at least 2 hours afterwards, either. The goal is to get the serrapeptase into your blood so it can go to wherever in the body it is needed. It is being used in Japan and Europe to clean up dead cells/tissue in the body, as well as reducing pain and inflammation.
Intestinal absorption of serrapeptase in rats.
Biotechnol Appl Biochem. 1994 Aug;20 ( Pt 1):101-8.
A sensitive sandwich enzyme immunoassay for serrapeptase, an orally available anti-inflammatory proteinase, was established. Serrapeptase in the plasma was determined after its oral administration (100 mg/kg) to rats. The peak concentration was observed between 30 min and 2 h after administration. These results indicate that orally administered serrapeptase was absorbed from the intestinal tract and transferred into the circulation in an enzymically active form.