I have tried most of the pharmaceuticals and natural anti-fungals with little depletion of my chronic candidiasis. I was diagnosed by my infectious disease doctor with thrush, which he cultured and attempted treatment with Diflucan and Nystatin. Also, my OBGYN has diagnosed me with chronic vaginitis...my 6 year old daughter has as well. Does that cover your criterium? I would be up for trying anything that is safe and possibly an end to this horrible illness.