Re: Will Lugol's kill MRSA? (edit)

http://www.worldwidewounds.com/2004/november/Thomas/Introducing-Silver-Dressi...
from this source:

For the management of infected wounds the following antibacterial agents may be considered:
Silver sulfadiazine and chlorhexidine (Silvazine), which has been shown to be effective against MRSA in vitro when tested against 50 strains of MRSA [65]
Preparations containing povidone-iodine, including Betadine Solution (10% povidone-iodine; PVP-I) and Betadine Cream (5% povidone-iodine) [66],[67]. One study, however, suggests that the antimicrobial activity of Betadine against MRSA was eliminated on dilution to one-quarter strength [68]. These results are at variance with others which showed that povidone-iodine, when diluted 1:100, was bactericidal against both MRSA and MSSA, killing all organisms within 15 seconds [69]
Preparations containing cadexomer iodine, which reduced the number of MRSA bacteria in wounds in an animal model, led the authors to conclude that it might be effective in preventing the proliferation of MRSA in wounds [70]
Silver sulfadiazine, which performs reasonably well in the laboratory [71], has proved to be less effective than mupirocin both in vitro [72] and in vivo [73]. Yoshida et al [74] applied a cream containing 1% silver sulfadiazine (Geben cream) to 13 patients with skin lesions infected with MRSA and found that the organism was eradicated from only 45.5% of 11 evaluable patients
The use of honey for infected wounds is increasing in popularity and a number of dressings or preparations containing it are now available, some of which have been shown to possess good antimicrobial activity against a wide range of pathogenic organisms, including resistant strains [75],[76] .
Other agents that have been recommended for the treatment of MRSA infections include tea tree oil [77] and gentian violet ointment [78], which was claimed, on rather doubtful evidence, to be more effective clinically than povidone-iodine in removing MRSA from pressure ulcers [79]. Extracts of tea are also said to have inhibitory effects on MRSA [80], even at the concentration achieved in infusions prepared for drinking [81].
Ultraviolet light at 254nm has been shown to kill MRSA in vitro [82] and it has been suggested that it might be suitable to treat clinical infections provided that exposure times are appropriate. However, the light is unlikely to penetrate deep enough into the tissues to eradicate the organism, particularly in the presence of slough or necrosis.
In such situations a treatment that combines debridement with effective antimicrobial activity is desirable and the use of sterile maggots of the greenbottle fly Lucilia sericata has been reported to rapidly cleanse wounds of slough and eliminate infection [83].
Given the problems of finding an effective form of systemic therapy for highly resistant bacteria, the importance of selecting an effective topical treatment cannot be over emphasised. After a study that compared the sensitivities of MRSA isolates collected from 44 consecutive patients against a range of antimicrobial agents, Smoot et al argued that all hospitals should regularly test the materials they use in order to provide the most appropriate form of therapy [84].

One family of dressings that has recently generated a great deal of interest with regard to the treatment of infected wounds depends on the pronounced antimicrobial activity of silver ions. Metallic silver has been used empirically to prevent the growth of micro-organisms since at least the time of Aristotle, who advised Alexander the Great (335 BC) to store his water in silver vessels and to boil it before use. According to White, the preservative properties of silver are still used for this purpose as water tanks on spacecraft are lined with silver to prevent bacterial growth [85]. The remarkable biocidal properties of silver have lead to its inclusion in a wide range of products, including clothing, several types of medical devices and many different types of dressings [86],[87].
Several excellent reviews have been published on the antimicrobial properties of silver and include information on its mechanism of action, development of bacterial resistance, toxicology, clinical indications and the historical background to its use [85],[88],[89],[90],[91].
Silver dressings
Metallic silver is relatively inert but the presence of liquid leads to the release of the silver ion responsible for its biological activity. Silver ions are biocidal at very low concentrations due to the ability of microbial cells to absorb and concentrate silver from very dilute solutions. However, the presence of organic matter significantly diminishes the efficacy of silver[92]. In complex organic biological fluids, concentrations greater than 50ppm [93]and as high as 60.5ppm are needed[94]. Once in the cell the silver binds to and denatures proteins, including DNA and RNA, inhibiting cell replication. Silver in solution exists in three oxidation states: Ag+, Ag++ and Ag+++. Each of these is capable of forming inorganic and organic compounds and complexes, although the Ag++ and Ag+++ forms are unstable or insoluble in water [91]. Ionic silver is active against a wide range of pathogenic organisms but not all forms of silver exhibit antimicrobial activity. Colloidal preparations in which the silver is complexed with albumin or other proteins were once used as antimicrobials, but their use was abandoned as they were shown to be ineffective. Nevertheless, preparations containing Colloidal Silver are still promoted on the internet and elsewhere as 'health foods', accompanied by extravagant and unsubstantiated claims of their beneficial effects on clinical disorders ranging from influenza to skin conditions such as cuts and warts [95].

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(personal note) …Here is a link to earth clinic with some material (this is what got me to cure zone..not this article… but another in fall 2007...I was doing research about “mrsa” as my wife developed “something” resulting from chemo (breast cancer treatment -summer 2007).

She used Turmeric “pills” as that's what I found in 2007…she (edit-hit wrong key) used/had been order/prescriptions of anti-meds/biotics which did NOTHING AT ALL the turmeric started working it about 12-14 hours… (side note ...She has been on Iodine (pill form- iodoral -late-late fall 2007) all tumor markers are/have been fine -last test was Feb 09. ..happy research/hunting..lucidhunt
http://www.earthclinic.com/CURES/boils_questions.html



http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=271835


Various commonly used antiseptics were tested against three strains of methicillin-resistant Staphylococcus aureus (MRSA) at stock strength and in serial 10-fold dilutions. The stock solutions of 4% chlorhexidine gluconate-alcohol (Hibiclens), 1% p-chloro-m-xylenol (Acute-Kare), and 3% hexachlorophene (Phisohex) produced 2-log reductions of MRSA after a 15-s exposure, but even after 240 s, these solutions failed to kill all the MRSA. Povidone-iodine (Betadine) solution was maximally effective at the 1:100 dilution, killing all the MRSA within 15 s; other dilutions were less effective, though each killed the MRSA within 120 s. Similar results were obtained with three different strains of methicillin-susceptible S. aureus. Thus, of the four most commonly used antiseptics, povidone-iodine, when diluted 1:100, was the most rapidly bactericidal against both MRSA and methicillin-susceptible S. aureus.




http://www.springerlink.com/content/c47158353m07j733/

From above link:
Abstract The topical application of a mixture of Sugar and povidone-iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting reepithelialization and granulation tissue formation, as well as by having an anti-microbial effect. In order to clarify the efficacy of a 70% Sugar and 3% PI paste (U-PASTA™)(SP) on infectious skin ulcers, we made a bacterial infection model using methicillin-resistant Staphylococcus aureus (MRSA) on the skin of diabetic db/db mice, and investigated the effect of the paste on the healing process of wounds. Full-thickness wounds were made on the backs of female diabetic mice, (C57BL/ksJ db/db) and inoculated with S. aureus. SP was applied to the closed wounds for 8 days. The degree of repair was evaluated using three histological parameters: The degree of reepithelialization was given a percentage value of 0–100%; the amount of granulation tissue was quantified by measuring the area of granulation (mm2); and the number of capillary lumens in the granulation tissue was counted in the complete wound cross-section at 100× magnification. In addition, the colony-forming units (CFU) of MRSA on the wounds were counted. Continuous MRSA infection in the wounds of db/db mice was demonstrated with macroscopic and histopathological images. Wounding and infection caused by MRSA on the back of the diabetic mice significantly induced delayed reepithelialization, granulation tissue formation with inflammatory cell infiltrate and increased CFU on wounds (P < 0.01, respectively) compared to those of the MRSA-infected normal mice. Application of SP significantly accelerated reepithelialization (P < 0.01) and decreased CFU (P < 0.05) of the ulcers in the MRSA-infected wounds, compared to the non-treated group. Histopathological evaluation and CFU on this animal model revealed no significant difference between Methicilin-sensitive Staphylococcus aureus and MRSA infection. These results indicate that wounding on db/db mice provides a useful animal model of bacterial skin infections, and that SP is an effective topical agent for the treatment of diabetic skin ulcers.

Great post/*value the viewer’s post from “summerops77“ on mrsa and another post on tumeric:

http://www.conspiracycafe.net/forum/index.php?showtopic=18239