Re: Hepatic encephalopathy and Ornithine study

I have no doubt I did damage to my liver spraying the herbicides for my work 10 years ago. We'll see if this makes a difference, but it makes alot of sense to me for what the ND and I have both over-looked for the chronic liver problems to continue.

I'm doing my own "trial", but even MD's are recognizing it.

http://clinicaltrials.gov/ct2/show/NCT00433368


There is no effective treatment available for hepatic encephalopathy at the moment; therefore we aimed to check the efficacy and safety of L-ornithine L-aspartate(LOLA). It provides critical substrates for ureagenesis and glutamine synthesis, the two primary mechanisms by which the body rids itself of excess ammonia. Ornithine is a specific activator of ornithine carbamyl transferase and carbamylphosphate synthetase, and, in addition, is a substrate for ureagenesis. These reactions are carried out mainly in the periportal portion of the hepatic lobules. Aspartate and ornithine, after conversion to alfa-ketoglutarate, are substrates for glutamine synthesis, which is performed exclusively by a small population of perivenous hepatocytes, the so-called perivenous scavenger cells. The ammonia lowering effect resulting from the stimulation of these two basic mechanisms of ammonia detoxification has been studied in animals and was confirmed in humans in clinical trials.