Good idea where I can start.
So your idea was that Hipoxia could trigger disturbance in DNA replication process that result in such a big structural change from Eucariot to procariot organism and vice versa
( yeast to bacteria or vice versa ). But still how to reasonably accept the thesis of pleomorphism that in few generations ( it is not a lot of time ) for example some organism could gain nucleus or other could loose nucleus.
For example some aerobic bacteria in our body could transform in yeast cell or anaerobic bacteria?
According to this we're constantly exposed to risk by ingesting probiotics or some other aeoribic friendly bacteria. Because if we aditionally support the culture by increasing the number in our enteric intestinal system we increase the need for oxygene. This way we risk that we're unable to provide through our body metabolism enough oxygene and aditionly raise the risk for this change. And according to this this could be very frequent.
In the mean time I'll try to study your article on Hipoxia as the form of cell signall in genetic material. I hope someone else is changed by similira questions.