All of this is inter related. Copper toxicity tends to promote fungal overgrowth. Pyroluria may be genetic for some, but may also be caused by a mircrobe; a fungi.
It's common for pyrolurics to have a copper or histamine imbalance.
Chicken and egg scenario, when we're trying to probe into all of this. Not quite sure what causes what. It seems in pyrolurics the immune system and probably the gut are breaking down.
My Kp level was 57. My white blood cell count was borderline low. Hair copper levels was 210, putting me in the 99th percentile.
Pyroluria is a sign that SEVERAL things have already gone awry in the body. At least, that's how it is with myself. Low histamine levels, high copper, and pyroluria.