Esophageal cancer linked to osteoporosis drugs

BOSTON (Reuters) - Merck's popular osteoporosis drug Fosamax and other similar drugs may carry a risk for esophageal cancer, a Food and Drug Administration official said on Wednesday.

Diane Wysowski of the FDA's division of drug risk asessment said researchers should check into potential links between so called bisphosphonate drugs and cancer.

In a letter in Thursday's New England Journal of Medicine, Wysowski said since the initial marketing of Fosamax, known generically as alendronate, in 1995, the FDA has received 23 reports in which patients developed esophageal tumors.

Typically, two years lapsed between the start of the drug and the development of esophageal cancer. Eight patients died, she reported.

In Europe and Japan, 21 cases involving Fosamax have been logged, with another six instances where Procter & Gamble's Actonel or risedronate and Didronel or etidronate, and Roche's Boniva (ibandronate) may have been involved. Six of those people died.

Esophagitis, which is an inflammation of the lining of the tube carrying food to the stomach, is already know to be a side effect of the drugs, which is why patients are instructed to remain upright for at least a half hour after taking them.

the rest...

http://www.reuters.com/article/scienceNews/idUSTRE4BU4TX20081231?feedType=RSS...


Take home message from a long history of drugs rushed to market based on short term trials, is that the public IS the long term trial... and experiment.

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