Many people have distortions in their colon....strictures, prolapses, ballooning, diverticuli...but as long as you don't have a total obstruction (you DO poo, right?!) you can benefit from the cleanses. Any toxins you remove will improve your health. Some of these consitions are caused from poor diet, lack of exercise, stress, unhealthy digestion and the accumulation of toxic material...clean up your body and some of these may resolve on their own. Slant board exercises can also help.