I had quite a prolonged reaction after my fifth liver cleanse. I felt quite sick for 3-4 days, and had a minor rash on my back, which subdued by itself in a few days. I think each person accumulates different kinds of toxins. And when they are released you might get different kinds of reactions for different people. But this should encourage you go GO ON. Till u get rid of all the bad stuff accumulated in your liver and GB. I'm onto my 8th cleanse now, and feel much better with each one !