I have pyroluria and got much worse on b6 and zinc taken at the same time. A doctor told me they combine and destroy each other they form a compound and are depleted . Take them at least 10 hours apart. You can confirm this by calling Vitamin diagnostics lab. The doctor there said the same thing . You are making yourself sick. I got hives from the sun when I took the two together. I got depressed, forgot things got carpel tunnel .I told the lab a doctor said there is no information to prove that and The lab said the doctors don't read the information they are sent.My kryptopyrrole levels were 200. I have been though some bad times with this and I thank God I found a doctor who knew what he was talking about. I see too much of this problem on these blogs and had to write this . I hope people see it and get help. God bless