I take small doses of hydrocortisone only once per week now in a shot- along with pregnenelone, dhea, folic acid, and B12. I have found much help with hydrocortisone as well. I was taking larger doses at first but feel that I don't need it as much now that my adrenals seem to be stronger. I will eventually wean off of the shots. I have found great help with isocorts- glandular adrenal. I get them from my doctor but you can order them off of the internet, you don't need a prescriiption. I also like the adrenal support formula offered by jarrow, this is herbs to strengthen the adrenals over time- not a quick fix such as the isocorts. I take around 8 isocorts per day but everyone is different. Some day's I need a lot and some days only a little, depends on my energy level. When I am feeling tired I take some, 2 at a time and I always take 2 in the morning with my glass of water with Sea Salt . I also take them before bed, they help me stay asleep. How much hydrocortisone are you taking?