I suggest checking out his entire site. He talks about irrigation. The solution (for spray or irrigation) is typically made by a compounding pharmacy. Need a really good MD who thinks outside the box and works directly with this type of pharmacy, if you want a scriipt. Have you worked with an integrative medicine specialist? If no - find one!
At the present time, patients are being treated with irrigation with topical antifungals such as Amphotericin B. The Mayo clinic has found that 75 % have an improvement. A paper was presented at the American Academy of Allergy, Asthma and Immunology meeting in 2004 which compared 6 months of irrigation with Amphotericin (250 micrograms/ml) vs. a placebo. There was a statisticly significant difference in the amount of mucosal thickening on the CT scan as well as endoscopic scores. In addition there were changes in levels of interleukin-5 and eosinophil-derived neurotoxin. There has long been a concern that there were no double blind studies done on use of antifungal agents. This should help in that regard. The Mayo clinic is now recommending a concentration of 100 micrograms/ml, however.
A study has begun which will hopefully lead to the approval by the FDA of the first treatment for chronic sinusitis. This involves a new formulation of Amphotericin B. For more information on the study, please contact Accentia Pharmeuticals. If you are in the New York area, you can contact our office (212-517-6611).