Anthelmintic Study - Papaya Latex, Other Medicinal Plants & Fruits

Several links for research. The papaya laxtex is different from ficin latex (previous post) -- both are being studied:

http://www.ncbi.nlm.nih.gov/pubmed/7706684

J Helminthol. 1994 Dec;68(4):343-6.

Effect of papaya latex against Ascaris suum in naturally infected pigs.

Danish Centre for Experimental Parasitology, Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg.

An experiment was carried out to investigate the anthelmintic activity of papaya latex (Carica papaya) against natural infection of Ascaris suum in pigs. Sixteen naturally infected pigs were, on the basis of faecal egg counts and body weight, allocated into four groups, each of four pigs. Three groups (groups B, C, and D) were given papaya latex per os at dose levels of 2, 4, and 8 g of papaya latex per kg body weight, respectively. The fourth group (group A) served as a non-treated control. Results of post mortem counts on day 7 post treatment revealed worm count reductions of 39.5, 80.1 and 100% in groups B, C, and D, respectively. Some of the pigs receiving the highest dose of the latex showed mild diarrhoea on the day following treatment. Otherwise, no clinical or pathological changes were observed in the treated animals. The possible future use of this traditional herbal medicine for livestock and humans is discussed.

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http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7G-4CF5B1C-2&...
_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&
md5=acdea566629ba0f711c06782563bcd72

Trends in Parasitology
Volume 20, Issue 7, 1 July 2004, Pages 322-327

doi:10.1016/j.pt.2004.05.003   
Copyright © 2004 Elsevier Ltd. All rights reserved.

ABSTRACT
Infections with gastrointestinal nematodes have severe consequences for the health of millions of people worldwide, and cause serious economic losses in livestock farming. Current control relies heavily on anthelmintic drugs, to which resistance is now developing rapidly. Plant cysteine proteinases, from the fruits or latex of plants such as papaya, pineapple and fig, have high proteolytic activities that are known to digest nematode cuticles, have low toxicity and have been used in traditional medicines against gastrointestinal nematodes for decades. These proteinases constitute strong candidates for a much needed alternative strategy for the treatment of gastrointestinal nematode infections of both humans and animals.

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http://www.aitvm.kvl.dk/E_periurban/E6Satrija.htm

http://www.ansci.cornell.edu/plants/medicinal/papaya.html

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New Study  - Amino-acetonitrile Derivatives- Abstract

http://www.nature.com/nature/journal/v452/n7184/full/nature06722.html