I have been using MSM for awhile with great results (energy, balance etc.).
I presented it to my Mom, but she said she has an allergy to sulfur products... and thought not to take it. From research I could offer her no advice to whether or not that was a problem with MSM.
She is also on perscription drugs for menopause, high cholestral, and high blood pressure. I have been slowly introducing her to more alternative approaches.