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Re: Maria, please advice on required dosage
 
mpdela Views: 2,307
Published: 13 years ago
 
This is a reply to # 1,199,919

Re: Maria, please advice on required dosage


Hi Mark,

Sorry I didn't answer sooner but I was on the Conference call from 2:00p.m. to 4:48p.m.. 

My son's doctor prescribed

Enulose syrup (10gm/15ML) Take 30ml by mouth as needed = approximately 2tbsp.  (BE VERY CAREFUL BECAUSE IT MAY PRODUCE UNCONTROLLABLE DIARRHEA THE FOLLOWING DAY)

He prescribed neomycin 500mg 1 tab every 8 hours.

My son has never taken metronidazole so I couldn't tell you what is the appropriate dose, but I believe it is one every 12 hours according to http://jac.oxfordjournals.org/cgi/content/abstract/23/4/619 .  Metronidazole is one of the three recommended by the University of Washington, Seatle, (funded by NIH) see copy below.  http://www.genetests.org/query?dz=trimethylaminuria, click under Management on left side: 

Suppression of intestinal production of trimethylamine.  A short course of antibiotics to modulate or reduce the activity of gut microflora, and thus suppress the production of trimethylamine, is effective in some cases [Fraser-Andrews et al 2003 , Chalmers et al 2006]. Such treatment may be useful when dietary restriction needs to be relaxed (e.g., for important social occasions), or when trimethylamine production appears to increase (e.g., during menstruation, infection, emotional upset, stress, or exercise). Three antibiotics with different target organisms have been used: metronidazole, amoxicillin, and neomycin. Neomycin appears to be the most effective in preventing formation of trimethylamine from choline [Chalmers et al 2006].

Laxatives, such as lactulose, to decrease intestinal transit time may also reduce the amount of trimethylamine produced in the gut.

 

 

 
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