I haven't tried it. I have used carrier waves and I could tell it was getting in areas that it didn't before. The frequencies may interfere with each other and change the MOR. Only one way to find out. If your using a positive offset square wave with a carrier wave it might not matter as it will kill anything per Hulda Clark .
Hoyle who worked with Rife hid the frequencies by using 2 frequencies together which did change the MOR.
I always just go for not much more than 30 minutes at a time. Try using less frequencies or dwell time. Don't turn it into something you don't like to do.