TMAU treatment recommended by U.S. National Institute of Health and others

Hello everyone,

Since I wrote this info within somebody else's post under a completely different title, since some people on this post seem to refer others to it who have a difficult time finding it, I'll try to recapitulate it in this post under an easier to locate title.

First and foremost, I can’t over emphasize enough how important it is for you to try to get yourselves tested for TMAU and/or Candida (as hadenuff29 did) by a doctor who is familiar with these concepts or that is opened to research it. I’m sure there are many other causes for Body Odor , and if you get tested and diagnosed, please let us all know so that we can help you find solutions to your problem. While you do get tested and wait for the results, you can start a treatment plan that can work on at least decreasing the intensity of your odor.

Well, the U.S. National Institute of Health and other government medical entities have published the following for TMAU sufferers:

In case you don’t receive the complete email address when I send it over, I’ll guide you along some of the websites for you to be able to display it.

http://www.genetests.org

then click on Gene Reviews, and search for Trimethylaminuria under the Search by Disease engine, and finally under Reviews you'll find a wealth of information.

Also see
http://rarediseases.info.nih.gov


1. RIBOFLAVIN (Vitamin B2) SUPPLEMENTS: 30-40 mg three to five times per day with food to enhance residual FMO3 enzyme activity. THIS WOULD POSSIBLY ONLY BE NECESSARY IF YOU HAVE TMAU. Enhancement of residual FMO3 enzyme activity with Supplements of riboflavin, a precursor of the FAD prosthetic group of FMOs, may help maximize residual FMO3 enzyme activity.

The website
http://rarediseases.info.nih.gov
states that “Taking riboflavin (Vitamin B2) enhances any residual FM03 enzyme activity, and they recommend to take 30-40mg 3 to 5 times a day with food (a low choline diet). It might be a coincidence, but his odor has decreased significantly since he started taking it, and this might support the idea of him having TMAU. We’ll see after the results of his TMAU test comes in. Who knows, maybe he was indeed born with a compromised bad gene that produced low amounts of FM03, and the Accutane Acne treatment “finished it off”.

Always read the lable on all products, especially Vitamin B complexes because I read in some of the bottles that Vitamin B50 contains Choline, which is what the lack of the liver enzyme FM03 cannot break down during it’s digestion in the intestines, and thus leaves the undigested food full of trimethyline which smells like fish, and is an extremely pungent odor that seeps through the sweat on your skin, especially in the groin and vaginal area, and in your breath.
2. Sequestering of trimethylamine produced in the gut:
• Activated Charcoal: 750mg twice daily for 10 days
• Copper Chlorophyllin: 60mg three times/day after meals for 3 weeks

Since activated carbon has been used for thousands of years by many societies, and I believe the Chinese and other Asian countries have been using it for thousands of years for gas and bloating, it has stood the test of time to significantly minimize odors. It is used in lots of chemical plants specifically to decrease chemical odors and for other reasons to. Europeans have been using it also for many, many years, and I know that my relatives in Cuba have used it for generations.

Chlorophyll is an ingredient that makes plants green, and they say that green vegetables are good for you. Chlorophyll is also a deodorizer in the intestines, so just the combination of both are very effective at significantly decreasing or eliminating Body Odor . But what dose and length of time should we take it?

3. LAXATIVES, such as LACTULOSE
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682338.html,
as needed: decrease intestinal transit time may reduce the amount of trimethylamine produced in the gut. Be careful because you don't want to have accidents in the wrong places. Don't overdo it to become dehydrated with diarrhea. A simple intestinal cleansing every once in a while helps. I'll send you alot more info on this in a following message.

Lactulose comes as liquid to take by mouth. It usually is taken once a day for treatment of constipation and three or four times a day for liver disease. Your prescription label tells you how much medicine to take at each dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lactulose exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. To improve the taste of lactulose, mix your dose with one-half glass of water, milk, or fruit juice

You can also use other laxatives, such as rubbing Castor Oil (an over the counter laxative) on your lower abdomen to produce intestinal cleansing. Be careful because you might produce a strong reaction, so make sure you’re near a bathroom. Castor Oil can also be used as a rub-on treatment for muscle tension and sprain. My father-in-law said that in his childhood days, it was used to soften the very tough leather on their baseball catcher’s glove – so it is very potent on the intestines just by rubbing it on the skin.

4. Suppression of intestinal production of trimethylamine: A short course of Antibiotics to modulate or reduce the activity of gut microflora, and thus suppress the production of trimethylamine. Such treatment may be useful when dietary restriction needs to be relaxed (e.g., for important social occasions), or when trimethylamine production appears to increase (e.g., during infection, emotional upset, stress, or exercise) Antibiotics recommended for trimethylaminuria to suppress production of trimethylamine by reducing bacteria in the gut:
• neomycin – appears to be the most effective in preventing formation for trimethylamine from choline
• metronidazole
• amoxicillin

5. The Trymethylaminuria Foundation located in Central Station New York, sent me literature recommended PROBIOTICS, to replace the “friendly bacteria” normally found in the gut that may inadvertently be removed with the laxatives and Antibiotics . This product, acidophilus, is found in some milk products, yogurt, and even in pill form. HOWEVER, MAKE SURE IT HAS BEEN KEEP IN A COLD STORAGE, because the bacteria dies in warm room temperature. If you buy it from the pharmacy shelf, the room temperature made it worthless. Usually, the pharmacist keeps it refrigerated.

6. Using soaps with a moderate pH, between 5.5 and 6.5. Trimethylamine is a strong base (pH 9.8), thus soaps with pH closer to that of normal skin help retain the secreted trimethylamine in a less volatile form that can be removed by washing.

AND LAST BUT DEFINITELY NOT LEASE, THE LOW CHOLINE DIET:
The U.S. Department of Agriculture, Nutrient Data Laboratory, Agricultural Research Service has posted online the following pdf file, the USDA Database for the Choline Content of Common Foods:

http://www.nal.usda.gov/fnic/foodcomp/Data/Choline/Choline.pdf.

It is the most comprehensive list I've found, although it lacks info of alot of foods.

Best of luck
mpdela Tweet