The "recommended" dose is to go 1 drop twice daily, then 2, then 3, then 2, then 1, then take 5 days off and do it again. You can continue going "up", increasing as you feel led to. Pulsing detoxified like this (days on and days off) seem to work best for most.
Remember to read the FAQs for companion supplements. Please read from http://www.iodinesource.com
for other wonderful information, which includes what mercury can do. (Read the section on the thyroid, there!)